This is in line with studies indicating differences between controls and self-diagnosed electro-hypersensitive patients in objective biological measurements such as cortical excitability [ 39], sympathetic skin response, brain responsiveness [ 97] and heart rate variability [ 98].
Latency is a clinical state characterised by purified protein deriviative (PPD) skin test responsiveness coincident with a lack of clinical representation of disease.
In further support of this idea, there are data which have linked variation in skin vasoconstrictor responsiveness to polymorphism in the glucocorticoid receptor gene [ 25].
We demonstrated that patients defined as having asthma resistant to standard therapeutic doses of systemic glucocorticoid were more likely to demonstrate reduced skin vasoconstrictor responsiveness to potent topically applied glucocorticoid [ 16].
For example, compared with subjects with diabetic peripheral neuropathy (DPN) alone, subjects with Charcot neuroarthropathy (CNA) demonstrate distinctive small nerve fiber neurologic deficits and skin vascular responsiveness that may predispose to ulceration (8– 10).
In the periphery, functional impairments in the small vessels, such as impaired endothelial function of the forearm resistance blood vessels or impaired skin microcirculatory responsiveness, are associated with cardiovascular risk factors [ 15, 16] and end-organ damage (intraventricular septal thickness or urinary albumin excretion ) [ 17].
Secondary outcomes were bronchial hyper-responsiveness (BHR), forced expiratory volume in 1 s/forced vital capacity ratio and skin prick test responses.
Thus, both of these long-lived mice, with alterations in GH and/or IGF-1 action, showed augmented ATF4 levels in liver and heightened ATF4 responsiveness in skin-derived fibroblasts subjected to oxidant or ER stress.
The phallus is both soft and hard, in other words, aggressive in its height and unmodulated shape, yielding in the responsiveness of its skin to stark Catalonian light.
Comparison of neural responsiveness to specific skin sites in detection and discrimination conditions took into account all relevant electrodes across the four experimental runs that continued into discrimination.
