Prendergast BJ, Cable EJ, Patel PN, Pyter LM, Onishi KG, Stevenson TJ, Ruby NF, Bradley SP. (2013) Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system.
We found that resistant species have reduced skin inflammatory responses and increased expression of genes involved in skin integrity.
AD is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers and skin inflammatory responses driven by cytokines expression.
CXCL2 was up-regulated in our dataset and has been shown to be chemotactic for neutrophils and to be involved in modulation of skin inflammatory responses [ 61, 62].
In addition, transgenic expression of Smad7 in the mouse skin could reduce inflammatory response and NFκB activation [ 36].
Histological analysis revealed that low-dose UV irradiation hardly induced skin injury and acute inflammatory response disappeared after 7 days.
Acute ultraviolet (UV) B exposure of the skin produces sunburn, an inflammatory response evident visually as erythema and characterized histologically by a mixed dermal neutrophilic and lymphocytic infiltrate.
miR-155 acts as an important player in controlling the inflammatory response during skin repair; genetic deletion of miR-155 in mice leads to accelerated healing associated with elevated numbers of macrophages and increased type-1 collagen deposition in wounded tissue30.
Mast cells lie in close apposition to blood vessels in dermis; therefore, chymase mediated conversion of 31 kD IL-1 beta might be expected to have a critical role in the initiation of the inflammatory response in skin.
These models were chosen because chemokines, in particular CCL5, facilitate direct communication between the innate and adaptive immune responses and are known to act as key mediators during the full development of the inflammatory response in skin diseases.
CXCL10/CXCR3 and CXCL13 may contribute to the inflammatory response, especially skin manifestations thereof, in AOSD.
