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Trouble Starts Early The best predictor of bone strength in midlife and beyond is how well the skeleton was constructed in childhood and adolescence.
As an effective strategy of the drug discovery for peptide-binding GPCRs based on the natural ligands, beta-turn peptidomimetic compound library with benzodiazepine skeleton was constructed using solid and solution phase parallel synthesis with four different scaffolds containing Phe, Lys, Ser and Glu, respectively.
A linkage map skeleton was constructed using 70 SSR markers that were polymorphic between Suweon 542 and Milyang 23 and evenly distributed across the 12 rice chromosomes, with 4 8 markers per chromosome (data not shown).
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The skeleton is constructed step by step as a grid of metallic pipes and welded firmly, so that the regular spacing and porosity of the structure can be controlled as designed.
Many invertebrate skeletons are constructed from carbonate or silicate minerals, whereas vertebrate skeletons are instead composed of a calcium phosphate mineral known as apatite.
The skeleton map was constructed by R package "maps", then modified using Adobe Photoshop (version 14.0, X64).
To mark the sampling sites, a skeleton map was constructed by R package "maps" (https://cran.r-project.org/web/packages/maps/), then modified using Adobe Photoshop (version 14.0, X64).
-Ganoapplanin (122) feartured an unprecedented dioxaspirocyclic skeleton, which was constructed from a 2,4-dihydroxy benzoic acid and a bridge-ring compound 102 [48].
After the consensus bin map (skeleton map) was constructed, residual markers in each original bin of individual maps including all molecular tags of 70 RGH loci were re-introduced and assigned to their respective bin positions on the integrated map.
The dihydrothiopyran skeleton of 4 was constructed by the ring closing metathesis of 21 which was synthesized from but-2-yne-1,4-diol.
A unique structural skeleton for CCR5 antagonist was constructed and functionalized, resulting in a new series of small molecules to be synthesized and characterized.
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