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This enzyme is often used for carbon skeleton remodeling and thus is responsible for introducing significant structural and biological activity diversity into the pentangular polyphenol family (e.g., rubromycin, griseorhodin, lysolipin, and xantholipin).
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In this way every part of the skeleton is remodeled periodically over time.
Between 5 and 10% of the skeleton is remodeled actively at any given time; in osteoporosis, either osteoclast function is increased or osteoblast function is decreased.
To protect the skeleton from enlarged remodeling space created by PTH treatment as well as to attempt to obtain further gain in bone density and prevent any decline, a number of investigators evaluated the use of PTH in the presence of antiresorptive agents that would prevent cortical bone remodeling and bone loss.
The skeleton is constantly undergoing remodeling.
Adult skeleton constantly undergoes bone remodeling to replace old/damaged bones by new bones, which is required for the maintenance of bone shape and strength of adult skeleton.
Bone is a high turnover tissue, resulting in the entire skeleton being totally remodelled in approximately 10 years.
The skeleton is continuously remodeled throughout the lifetime of an individual, and this remodeling is a dynamic process by which bone resorption is coupled to bone formation, to replace damaged bone or to respond to metabolic needs [ 40].
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation.
Considerably less is known about the role this growth factor plays in the coordinated development, growth, and remodeling of the craniofacial skeleton beyond embryonic stages.
Bone is continually renewed throughout the skeleton in a process known as remodeling.
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