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In summary, Wnt4 is expressed during skeleton development.
Most studies of Wnt signaling in skeleton development have been restricted to the chick model.
To study the actions of Wnt4 during skeleton development, we created a conditional genetic system to express Wnt4 during chondrogenesis.
Subsequently in chick, Wnt4 expression in the joint regions and misexpression studies indicated a role in skeleton development [5].
One dmrt2 gene is also expressed in the mouse embryo, where it is necessary for somite differentiation but with an impact on axial skeleton development.
In the mouse, it was shown that Dmrt2 is required for somite differentiation with severe implications on axial skeleton development [24].
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Although 'gracile' throughout her entire skeleton, muscle development (as exhibited by linea aspera and gluteal line development as well as deltoid tuberosity rugosity and definition), would be classed as moderate and about the expected condition for a female of this developmental age living in this environment.
Parathyroid adenoma, disorder characterized by loss of mineral materials from the skeleton, the development of kidney stones, and occasionally progressive kidney insufficiency.
If true, closely related animals should have similar microRNAs, just as they should have similar features of the adult skeleton, embryonic development, and DNA.
Axial skeleton disease development was assessed by histology and skeletal changes examined using DEXA.
In contrast to the pharyngeal skeleton, the development of the appendicular skeleton was relatively conserved among fish species (Fig. 5).
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