Sentence examples for skeletal healing from inspiring English sources
Our results indicate that the coculture of PB-CD34+ cells and MSC increases bony regeneration in calvarial critical-size defects in rabbits, and provide a new promising therapeutic strategy to aid skeletal healing.
Abnormalities in the innervation of the fracture site will slow skeletal healing clinically [ 13- 15] and experimentally [ 16- 18].
Thus, further elucidation of the molecular mechanism of Pb toxicity during skeletal healing and chondrogenic differentiation in developmental situations is of paramount importance.
Since abnormalities in fracture innervation will slow skeletal healing, we explored whether abnormal mRNA expression of genes related to nerve cell activity in the older rats was associated with the slowing of skeletal repair.
In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography (gamma scintigraphy or SPECT), ex vivo micro-computed tomography, and histology to monitor 99mTc-MDP uptake in injury sites during skeletal healing.
Here, we alert the reader to recent findings demonstrating that the HIF-1α pathway is activated during bone repair and can be manipulated genetically and pharmacologically to improve skeletal healing.
Macrophage involvement is clearly a prerequisite for skeletal muscle repair and their deregulation can determine the outcome of skeletal muscle healing.
In a mouse model, adipose- and bone marrow– derived MSCs are equally effective in healing skeletal defects; adipose-derived MSCs are also able to heal bone defects in a rat model.
Our results provide a greater understanding of the skeletal muscle healing process after injury or from disease, and will shed light on the role of cellular dedifferentiation in regenerative medicine.
Yet, strong depletion of monocytes only partially impairs skeletal muscle healing, supporting the existence of alternative mechanisms to palliate the loss of infiltrating macrophage progenitors.
Given the critical involvement of macrophage subsets in skeletal muscle healing, a better understanding of the mechanisms governing their accumulation may reveal new points of regulation for intervention.
