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Warkany and his associates found that feeding defective diets to normal breeding rats produced offspring with skeletal defects.
Orthopedic surgery deals with the bones, tendons, ligaments, and muscles; fractures of the extremities and congenital skeletal defects are common targets of treatment.
Various techniques have been advocated for reconstruction of skeletal defects after limb salvage.
One well-known frozen model is Loop Tail, used to study skeletal defects.
Engineered cell-based constructs are an appealing strategy to treat large skeletal defects.
The emergence of orthobiologics holds great promise for large skeletal defects.
Skeletal defects impose a significant burden on the US healthcare system.
The repair of skeletal defects remains a substantial economic and biomedical burden.
Bone tissue engineering is a promising therapeutic alternative for bone grafting of large skeletal defects.
Current reconstructive approaches to large craniofacial skeletal defects are often complicated and challenging.
Endoprosthetic replacement for the management of trauma may have a limited, but a defined role in addressing skeletal defects.
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