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In children, stunted growth may be the first symptom that leads to detection of the kidney disease; the skeletal abnormality cannot be ascribed solely to an abnormal mineral balance but is probably also due to an adverse effect of uremia on protein metabolism.
Mice expressing Cre only did not exhibit any skeletal abnormality relative to WT mice in deferent studies and no abnormal phenotype was observed in our analysis.
Polyostotic fibrous dysplasia was first described by Lichtenstein [1], as a skeletal abnormality where the medullary cavities of multiple bones were filled with 'gritty, greyish white fibrous tissue containing trabeculae of newly formed primitive bone'.
For complex cases of skeletal abnormality, particularly those requiring combined orthodontic/surgical management, a large FOV CBCT may be justified for planning the definitive procedure, particularly where MSCT is the current imaging method of choice [6].
FGF signaling is crucial for skeletal development, exemplified by the mutations that disrupt FGF signaling in human genetic skeletal abnormality syndromes [27].
A radiograph was obtained postoperatively to verify correct implant position and to screen for skeletal abnormality.
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The resulting risk of mental retardation, eye problems, skeletal abnormalities and stroke can be reduced by a special diet and high doses of vitamin B6 or B12.
This is especially intriguing because Kennedy's autopsy report found "no significant gross skeletal abnormalities," aside from the bullet wounds in the skull.
Adrenal corticosteroid hormone is associated with skeletal abnormalities, osteopenia, and osteonecrosis.
Those infants that survive may be born with rashes, pneumonia, and skeletal abnormalities.
The bone abnormalities develop more slowly than kidney insufficiency; if the latter is severe, death may occur in childhood before the skeletal abnormalities become apparent.
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