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Based on the sizes of risk areas and the significance of clusters, important risk factors shared by neighboring areas could be uncovered.
GRPS are constructed in two steps: firstly, individual effect sizes of risk alleles (e.g., beta from linear regression, odds ratio from logistic regression or best linear unbiased prediction (BLUP) from linear-mixed models (Yang et al. 2014)) are estimated in the discovery sample.
With international support from the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS), a first published estimate of the size of the problem was derived combining estimates of the sizes of risk populations in the various provinces with estimates of HIV prevalence per risk group available from national surveillance sites in 2003.
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On March 27th, Bank of Tokyo-Mitsubishi admitted to $50m of derivatives losses run up by its New York branch because its computers had miscalculated the value of its trading positions.Banker, control thyselfStill, bank bosses are placing more confidence in the ability of these whizzy new toys to measure the sorts and sizes of risks their firms run.
The size of risk of breast cancer found in Hodgkin's disease patients has varied between studies.
Odds ratios with 95% confidence intervals were calculated to estimate the effect size of risk factors associated with complete recall.
The true genetic architecture (in terms of number, frequency and effect size of risk variants and the way in which they combine) is unknown and may be quite different for the different diseases listed in Table 1.
The effect sizes of the risk alleles were similar to what they were reported in other ethnics [18].
Our study has uncovered a bias for stronger effect sizes of SLE risk alleles in Southern Europeans than in Central Europeans.
The results showed a bias to larger effect sizes of the risk alleles in the Southern Europeans relative to the Central Europeans.
He once told me, for example, that he believed the way to deal with systemic risk was to adopt a cap-and-trade approach, where the government would set an all-encompassing risk ceiling, and firms could then buy and sell pieces of that risk, depending on the size of their risk appetites.
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