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We consider three scenarios with different sizes of cases and controls.
When sample sizes of cases and controls increase to 1000 vs. 1000, which is currently not a problem for most genetic association studies, the model has almost full power to detect three-locus epistasis of different forms.
Diagnostic standard of each study, sample sizes of cases and controls, genotype numbers, allele frequency in both cases and controls, and P values of HWE in controls were summarized in Table S2.
a: weighted according to the matched sizes of cases.
Larger sample sizes of cases and controls will definitely increase power to detect COPD susceptibility loci.
This is repeated for our study by changing the sample sizes of cases and controls accordingly.
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Strictly speaking, the sample sizes of case and control should be greater than 4 for SWang(1,4) for consideration of the reliability of skewness and kurtosis.
The sample sizes of case-1, case-2 and control are 157, 140 and 151, respectively.
Means and standard deviations of the estimates of the disequilibrium coefficients and the corresponding LOD score from using various sizes of case-control samples.
In (4) and (5), symbols p and n are, respectively, the sizes of case data and control data, while in (4), (5), (6), and (7), P and N are, respectively, the sets of case data and control data.
Given the small sample size of cases within the laboratory hours no conclusion can be drawn.
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