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Five of the six loci showed stronger effect sizes of association with Stage III/IV disease, with the exception of VEZT.
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The effect sizes of associations with single SNPs identified by GWAs are generally low.
Effect sizes of associations between alcohol use and unprotected sex with a boyfriend or husband were lower than these associations with clients.
The effect sizes of associations were relatively small apart from the prevalence of conduct disorder between those with and without a parent with ADHD.
Moreover, although we had expected that the 500K SNP microarrays would identify a few SNPs with larger effect sizes, the average effect sizes of associations in the two studies were the same.
While this seems to be a reasonable assumption as many associations between SEP and health outcomes are linear [73] [75], in some cohorts this assumption may be violated and this would lead to an underestimation of the size of association between childhood SEP and physical capability.
Among the reviewed studies, 33 reported the effect size of association.
These inconsistencies are probably caused by ethnic differences and small sample size of association studies.
We saw no significant difference in the size of association during these two periods (test for effect heterogeneity, P=0.35).
For example, the addition of phosphorus intake to the multivariable model reduced the size of association of non-haem iron with systolic blood pressure by 38%.
Two-way tabulations and Fisher exact test were used to estimate the direction and size of association of individual variables with sequence types.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com