Several RCTs comparing protein levels in individuals with diabetic kidney disease with either micro- or macroalbuminuria had adequately large sample sizes and durations for interpretation.
With this three-class model, the class sizes were of reasonable magnitude for interpretation with 41 (10%), 317 (79%), and 43 (11%) of patients in each latent class.
Also, the vast size of the crown of mature aspen trees would eventually cause difficulties for interpretation when crown sizes of other trees were considerably smaller.
Effect-size estimates were also included for interpretation purposes.
Regulatory requirements are typically published in standard 'Guidance documents', but in practice the 'one size fits all' approach has room for interpretation for specific indications and clinical trials.
The authors provide a rationale for use of effect size and specific tools and guidelines for interpretation of results.
We chose standard deviation (as a summary statistic) and standard regression analysis for interpretation and sample size considerations.
Because of their small size, the cellulose patches provide a novel approach for interpretation on the molecular architecture of cellulose.
Important questions may be also raised about which between-arm difference will be relevant, with implications for interpretation of results and sample size calculation.
The combined effect of radiation therapy and tamoxifen on MI was consistent across levels of tamoxifen duration, cumulative dose and recency, although small sample sizes limit interpretation (data not shown for dose and recency).
