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Effect sizes and variance ratios were computed.
We have also used the approach to design multi-country trials where each country's cluster sizes and variance parameters differ, but a common test across countries is desired.
Our implementation has range limits for the nucleosome sizes and variance to force the method to converge to 'reasonable' nucleosome sizes/variances in the early stage of the iterative process.
Lessons from the feasibility trial will be used to refine the intervention and gather the information needed for a definitive trial such as practicability of the intervention, recruitment and retention rates and effect sizes, and variance required for a sample size calculation.
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Due to the statistical bias of comparing data samples with very different sizes and variances (76 samples versus 11 samples), the error cannot be reduced further.
Tests involving categories 1 4 conservatively ran the risk of committing a Type II error (i.e., claiming no effect of development when one really exists) because treatment categories had smaller sample sizes and variances.
The most prominent procedures of this type, the Dunnett and Tukey-Kramer test, control the probability of reporting at least one false positive result when the data are normally distributed and when the sample sizes and variances do not differ between groups.
We abstracted effect sizes and variances, where available.
We used Games-Howell for post-hoc analysis, since both sample sizes and variances between seasons were unequal.
The Japanese trial had a weight of 82.78% and the European trial had a lower weight of 17.22% due to the different sample sizes and variances (inverse variance method).
We finally calculated pooled meta-analytic estimates for CDR 0.5, 1, and 2/3 compared with CDR 0 (i.e., no dementia), accounting for sample sizes and variances in country-specific estimates.
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