In this regard, DOR may belong to the group of proteins characterized by sizeable regions that lack a predicted well-structured three-dimensional fold, which show high conservation among species (from mouse to human in the case of DOR) and in which, contrary to the traditional view, the disordered region is functional [40].
About half contain sizeable regions C-terminal to the catalytic site, with a mean size of 110 aa, but none resemble the calmodulin-association regions of mammalian CAMKs.
Without a sizeable regional presence, the Pentagon will not be able to maintain the predeployed resources and equipment necessary to contain Iran, and Washington will signal its lack of commitment to every ally in the region.
Another sizeable part provides for differences in niche exploitation.
In some genes, the decay is extensive; sdrC encodes two premature stop codons, resulting in three putative transcripts separated by sizeable intergenic regions [29].
Standard DNA sequencing of sizeable gene regions in large study populations with the aim to identify the contribution of rare mutation is time-consuming and cost-intensive.
This was not surprising as it is widely accepted that regulatory regions can be found not only at 5' upstream regions and sizeable distances from the coding region, but also within protein-coding exons as is the case of enhancers of zebra fish developmental genes [ 32].
Finally, a sizeable intermediate parameter region exists within which β* > 1 and R2 > 1 at y* but R1 > 1at z*.
This structural variation (SV), which is often observed as large deletions or duplications, occurs on a scale from single genes to sizeable multi-genic regions.
A lack of critical recombinations in the family on this chromosome means that the linkage region is sizeable and the number of candidates in the hundreds, and this cannot be resolved by typing more markers in the region.
