Our initial assessment of three independent sets of patient tumors resistant to BRAFi suggests that the RNF125/JAK1 regulatory axis described here is relevant to a sizeable fraction of these tumors, which is a prediction that should be confirmed using larger cohorts.
Motivation: A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions (IDRs), which act in unfolded states or by undergoing transitions between structured and unstructured conformations.
He would, for instance, be confronted in reality with Einstein's famous "twin paradox," which hypothetically assumes that "a twin brother who takes off on a space journey in which he travels at a sizeable fraction of the speed of light would return to find his earthbound twin either older than he or little more than a dim recollection in the memory of his descendants".
However, no early TCR-induced Tyr505 dephosphorylation was detected at 2 min and both p56 and p59 forms of Lck were still phosphorylated on Tyr505 at 10 and 30 min. Thus, a notable change in Lck following anti-CD3 stimulation was the delayed appearance of p59, which was found to represent a sizeable fraction of Lck in Lck immunoblots (∼35 40% at 30 min).
This study points out by using a better scale like MoCA may help to identify cognitive impairment in patients with diabetes, which is associated with long term risk of cognitive decline and later dementia in a sizeable fraction of patients.
A sizeable fraction of AMPARs were present at the surface of synaptosomes and co-fractionated with NMDARs and PSD-95, indicating they were localized to synapses.
That's a sizeable fraction of that group's success.
The research program seeks to convert a sizeable fraction of this power into coherent radiation.
Electrolyte material costs constitute a sizeable fraction of the redox flow battery price.
Although catastrophic medical expenses strike only a tiny fraction of Americans each year, they account for a sizeable fraction of health care costs.
That represents a sizeable fraction of a professional, four-decade, career (more so if you add on the undergraduate years).
