It's not enough for anyone to notice straight away, especially when they hide everything in tiny codes on the monthly statements, but more than enough to be making a sizeable illicit profit once you add it all up.
Instead, their data indicate 1) that dopaminergic terminals contain the neurotransmitter GABA, 2) that GABA is present in or near VMAT+ synaptic vesicles, and 3) that the concentration of GABA is large enough to be detected in a sizeable fraction of dopaminergic terminals.
Expect to make a down payment that is sizeable enough to prevent the amount you owe from being more than what the car is worth.
The asymmetry was a consequence of the calf compartment having less endothelial surface area per volume and thus lower total surface receptor densities than the normal muscle compartment (supplemental Fig. S1), such that the second mechanism involving NRP1-VEGFR2 coupling was not sizeable enough to override the first mechanism involving sVEGFR1-VEGF association.
Continuing Avandia sales in the US are no longer sizeable enough to impact the investment thesis but people will extrapolate to future liabilities if the review turns brutal for Glaxo.
Step one was to identify high-potential relocation sites, sizeable enough to accommodate the town's growing population, with access to land and water and the hunting and fishing grounds on which the residents' ancestors had relied for generations.
But to do that, it needs a sizeable enough audience to encourage publishers' to pay — so this chicken/egg is not there yet.
Some farmers who were able to transfer livestock from the south either did not have land sizeable enough for pasture, or were not able to build enclosures, so livestock were often unconfined.
In fact, the increased pediatric use of medications has created, in some cases, a sizeable enough market to justify funding research programs specifically focused on pediatrics.
Our hMC4R in silico mutagenesis yielded a sizeable set of residues predicted to be functionally important.
