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In liquid cultures, cells progressively down-modulated Oct-4 expression while a sizeable cell fraction expressed CD34 de novo.
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The stage 2 tumor is a differentiating neuroblastoma, Schwannian stroma-poor, comprised of some immature neoplastic cells (∼10% of tumor cells) as well as a sizeable population of neoplastic cells that exhibit histologic features of ganglionic differentiation (∼90% of tumor cells).
We furthermore noted a sizeable increase in etsrp+ cell numbers in between 4 and 12 som (Fig. 2A-C).
Evidence supporting this is found in reports that a dentate spike, the spontaneous discharge of a sizeable population of granule cells, is reliably followed after an appropriate delay by a CA3 SPW [19].
With a solid morphostat block, a sizeable number of aberrant cells were created.
Our method sustains ~50% plating efficiency, making it possible to select for Thermotoga transformants among a sizeable population of viable cells.
Constitutive Ca2+ entry through the mutant channels, integrated over many hours, is therefore sufficient to stimulate NFAT and c- fos gene expression, at least in a sizeable fraction of the cells.
Glial cytoplasmic (Papp-Lantos) inclusions of multiple system atrophy (MSA) were NPTX2 positive (not shown) and in PD a sizeable number of glial cells expressed NPTX2 protein that appeared to be SNCA negative (Fig. 3).
Thus, whereas female RIP-DTr mice featured a sizeable number of beta cells (Fig. 6a) and a relatively high insulin content (on average 63% of the control levels; ESM Fig. 5a) up to 3 months after the DT administration, male mice featured a rapid, and close to complete, loss of both beta cells (Fig. 6b) and insulin (0.4% of control levels; ESM Fig. 5a).
A sizeable minority (18%) used multiple cell phones in the past seven days, but most (80%) reported multiple cell phones in their household.
These experimental results provide a simple means for the acquisition of sizeable quantities of immature stem cells from the de-differentiation of mature cells.
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