Table 4> -wrap-foot> summarises tumour location, tumour size, substitution of one base, codon affected, and predicted amino-acid substitution.
Pinguicula (butterworts), the third genus of Lentibulariaceae, is far less extreme in genome size, substitution rate and morphology, and exhibits glandular leaves that function as adhesive ("flypaper") traps.
The synthesised analogues of URB602 explored the biological effects of isosteric replacement, ring size and substitution, para substitution of the biphenyl moiety and the incorporation of a bicyclic element.
Bayesian analysis was then performed on the alignment in BEAST 1.6.1 [ 91], running 10,000,000 MCMC generations and logging every 1,000 generations, with the following departures from the default priors: constant population size; GTR+G substitution model with starting substitution matrix and gamma parameter values chosen using ModelTest.
We also tested for relationships between clade size and substitution rate within specific groups of mammals, as it has been shown that patterns of substitution rate variation and patterns of diversification can differ between these groups [ 27, 28].
Rational selection and design of dioxygenases, allied to substrate shape, size and substitution pattern, has been used to control regiochemistry and stereochemistry during the oxygenation process.
The spacing of these congeners in the physicochemical domain maximises the coverage of key factors such as molecular size and substitution pattern.
The influences of the position and size of substitution alkyl groups on HOFs and densities are discussed, and the magnitudes of the calculated HOFs and densities indicate that the studied PCU derivatives are promising high-energy density hydrocarbon fuels.
The decrease in Hc was due to the presence of impurity α-Fe2O3 which affected the crystalline and grain boundary since it has been reported that the Hc could be affected by important parameters such as particle size, ion substitution, morphology, interface structure, crystal defects, magnetocrystalline anisotropy, and strain [41].
We performed in silico molecular docking and dynamic studies and demonstrated that type and size of substitution at the C17 position of the cortisol backbone confer a unique stable conformation to GR on ligand binding that is critical for inhibitory activity.
In addition to the normal oligomer size distribution, substitution of H12 to Ala also yielded a smear of oligomers ranging from ∼12 to 20 kDa (heptamers to dodecamers).
