During the study sample size was revised based on observed accrual, outcome and crossover rates, with extended accrual and follow-up periods but no change in other assumptions, such that 261 outcomes in 390 patients would provide a study power of 75%.
Due to enrollment challenges, the total sample size was revised from 500 (original design) to 430.
MM participated in designing the experiments and data analysis, performed the experiments corresponding to the bacterial growth population size, and revised the manuscript.
The original sample size was revised because fewer patients meeting the eligibility criteria were available for recruitment within practices than had been anticipated.
The power and sample size were revised from the initial protocol (originally 400 patients per group) based on 1) a reassessment of the literature, resulting in a lower standard deviation for CIMT progression (originally 0.050), and 2) a lower than expected discontinuation rate, resulting in a larger evaluable sample than originally projected.
In the 1970s Maclean's, like other magazines, encountered rising production and distribution costs while circulation and advertising revenue declined, but it countered by reducing its page size and revising its format.
Tessa Jowell, the Olympics minister, accused opposition parties of not supporting the games and indulging in Victor Meldrew-style pessimism, and of "voting for Paris" as they criticised the size of the revised budget.
However, it is possible that with increased overall sample size and a revised experimental protocol that increases trials by individual birds, more subtle expressions of side bias could be found.
The sample size target was revised at a steering committee meeting on 2 August 2012.
Sample size calculations were revised to calculate what might be detected with a sample of 23000.
