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The estimated ICC from the blinded sample size review is also included in the SAP.
As this was a blinded sample size review, the p-value will not be adjusted in the final analyses [ 4].
Also, we performed regression analyses considering each of the risk of bias criteria as the dependent variable and year, sample size, review topic and funding as independent variables.
The most common reasons for exclusion were for results not applicable to the research question, not published in a major journal, small sample size, review articles, and duplicates.
The statistical analysis plan (SAP) was revised to reflect the change of the trial's design, the revised sample size and the blinded sample size review.
On recruitment of 700 patients, a sample size review will be carried out to determine whether additional recruitment of up to 1000 ICD patients is necessary.
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IGF-I is an angiogenic factor that affects fetal nutrition and size (reviewed in [46] and its expression is associated with alternatively activated macrophages [22], [47], in agreement with the angiogenic characteristics of this cell type.
Further, in preclinical studies GLP-1 has been shown to reduce infarct size (reviewed in reference 20).
Metazoan mitochondrial genomes (mitogenomes) are double-stranded circular DNAs typically 16 18 kbp in size (reviewed in [ 1– 3]).
Furthermore, we expect intracranial data to be fractal-like with observed dynamics dependent on electrode size (reviewed in Nunez 1995).
The Hippo signaling pathway has emerged as a key regulator of organ size (reviewed by Pan, 2010; Halder and Johnson, 2011; Tapon and Harvey, 2012).
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