First, the sample size of patients was small.
Finally, the small sample size of patients limited the number of variables entered in the multivariate analysis to three (SV, SAPS II and TBSA).
Genetic association studies are exposed to several biases, including phenotypic definition of the disease, adequate sample size of patients and controls, selection of the polymorphisms, and population stratification.
Some studies have been completed in the last decade, but most of them were retrospective or observational studies with small sample size of patients and controversial results.
Maybe the random distribution of the patients and the small sample size of patients in ACV and CPAP modes can also explain these differences.
We measured the distance from the lunate facet as well as the total distance of the radius and created a ratio to account for differences in the size of patients.
Jonathan Fox, of the Association of Professional Ambulance Personnel, said: "It is becoming increasingly frequent that the size of patients causes problems moving them and that in turn increases the risk of injury to staff.
Indeed, bleeding events were not observed in our study, possibly due to the small size of patients' population.
Therefore, given that mutational patterns were almost similar for carriers and non-carriers of nDNA mutations, the figures and tables presented in the main text refer to the total sample size of patients.
The sample size of patients infected with HCV genotype 4 was small (n = 28), limiting our ability to detect a significant association between the G allele and treatment failure.
Whilst the smaller 'infarct size' of patients with DM in the cohort free of prior CVD is significant, we again cannot explain this due to the observational nature of the study.
