To account for this we incorporated 'expansive' and 'restrictive' estimates of the population size, and examined varying degrees of overlap between the datasets defining our subpopulations.
What Nielsen does not know is the size of the overlap between app users and website visitors, which means it cannot give an overall traffic number.
The size of the overlap between drug targets and C.Prot is significantly large (176 proteins, P = 1.6E-23).
In Figure 2, we show the size of the overlap between the two methods as a function of the iteration of co-training.
Significance of changes in expression in pathways or networks is evaluated in the MetaCore™ suite based on the size of the overlap between user's dataset and a set of genes corresponding to a network or pathway queried.
For each combination of conditions in which the seed gene is DE, the size of the overlap between the top-ranked co-expressed genes in each dataset is tested statistically (Fig. 1 shows an example).
It is plausible that the degree of coordinated gene co-regulation by pairs of TFs, miRNAs or TF-miRNA regulators can be inferred by utilizing statistical association (interaction) measures for quantifying the significance and size of the overlap between the sets of predicted targets of each pair of regulators.
The thresholds used to assign a gene set to a miRNAapt were the following: 1) Gene set enrichment of anti-correlated targets: Fisher test p-value < 0.001 2) size of the overlap between each gene set and the list of anti-correlated miRNA targets > 3; 3) size of each gene set < 500.
The enrichment of a GO functional category (Ci) for a group of genes (G) was measured according to Pr i = ∑ 0 < k < m (M k ) (N − M n − k ) (N n ), where m is the size of the overlap between Ci and G. M and N are the size of Ci and all genes, respectively.
Overall, the user can specify seven algorithmic parameters: the method for calculating the starting tree, the number of taxa in each subset of a decomposition, the size of the overlap between subsets, the techniques for estimating alignments and trees on each of the small subsets, the supertree method used to construct a tree on the entire set of taxa and the stopping criterion.
