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As noted above, there was also a lack of independent assessments of the presence and size of improvements in conduct problems.
Since DCP was compared with good usual care, this may explain why the size of improvements in QALYs (0.037) and life-years (0.14 years) was small.
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Active rTMS showed a larger effect size of improvement for hyperarousal symptoms compared to sham; 24-h urinary norepinephrine and serum T4 increased; serum prolactin decreased.
The effect size of improvement and intention-to-treat (ITT) will be estimated.
This was maintained at 20 weeks where the effect size of improvement was unchanged at 1.1.
The size of improvement with the first TNF antagonist (-0.40) is within the range of what has been reported in clinical trials [ 44- 46].
Therefore, a percentage at the hospital level showing the size of improvement clusters seems appropriate in the context of presenting information to consumers.
The selection may influence outcome, for example, by increasing the average size of improvement by requiring a minimum severity or by excluding difficult-to-treat patients.
Given that medication vs. placebo had no differential impact on outcome, we examined the effect size of improvement for the sample as a whole to determine the impact of CBT.
Given no significant difference between medication and placebo we calculated the effect size of improvement in functioning for all participants at 15 weeks which was.5, and.44 at 20 weeks.
To compare the size of improvement in outcome scores in RCTs and observational studies, the standardized mean change (SMC) [ 13] was calculated for each RCT treatment arm and observational study by subtracting the follow-up mean outcome score from the baseline mean score and dividing by the standard deviation (SD) of baseline scores.
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