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Total size of altered genome and size accounted for by gains and losses was calculated by adding up the lengths of individual segments.
On average, the frequency of altered genome was 32% per tumor, and the size of altered genome per tumor was 946 Mbp (range 42-2137 Mbp). 42-2137 Mbp
Next, average number of changes and average size of altered genome were calculated for sporadic tumours and for each group of familial tumours.
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The chromatin changes did however exhibit heterogeneous characteristics; the sizes of altered chromatin domains varied on different repressed genes.
Finally, since some mutants showed differences in colony size suggestive of altered growth rates, we obtained the corresponding growth curves.
Different approaches have been developed because more traditional classification techniques, such as optical and electron microscopy, are hampered by the fine grain size of highly altered meteorites and can produce conflicting results.
Window sliding was carried out to estimate the size of the altered regions.
Similar tendencies were observed when using 3 different metrics to assess genomic instability (total size of the genome altered, fraction of probes altered, or number of altered segments identified; see methods section).
The benchmark simulations showed that sufficient inclusion populations with appropriate sizes are capable of altering the local flow patterns and destabilize the mushy zone, initiating the subsequent channel segregation.
Later, auralization was used to investigate the effect of realistic modifications to the room acoustics (acoustical treatment of a wall, change of the room size) by altering the virtual model of the classroom.
Ubiquitination of target proteins by Ubc4 could regulate SPB size by altering levels of SPB proteins or by affecting their incorporation into the pole, thereby changing the nucleation capacity of the SPB.
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