Pellet yield, size, shape, friability and drug release profile were studied, along with surface and interior morphology.
The droplet size and polydispersity index of the reconstituted microemulsion was almost unchanged after solidification, and pellet size and friability were all qualified.
Here, variables were studied and spheroids were characterized for average size, surface morphology, friability, bulk density and flow properties.
A D-optimal design (29 experiments) was used to assess the influence of process (screw speed, throughput, barrel temperature and screw design) and formulation parameters (starch content of the filler) on the process (torque), granule (size distribution, shape, friability, density) and tablet (hardness, friability and dissolution) critical quality attributes.
Pellets characteristics such as size distribution, sphericity, friability and drug release were also determined.
For dicalcium phosphate, the amount of fines (<125 μm), median granule size and granule friability were significantly influenced by extruder type and total input rate.
Differences between theoretical and real macro and micro effects over the grinding wheels after single-point diamond dressing, epoxy bond strength, abrasive protrusion, abrasive grit size and abrasive friability play a key role in the Ud-lap grinding.
Release studies were conducted, and the bead size, shape, yield, and friability were determined.
In all bowl volumes the influence of water concentration on actual yield, particle size distribution and granule friability was similar.
A surface response design with three formulation variables (binder, sorbitol and water level) and one process variable (spheronisation speed) was used to optimise the process and to evaluate pellet yield, sphericity (aspect ratio and two-dimensional shape factor, eR), size (mean Feret diameter), friability and disintegration properties.
