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Due to their size, difficulties arise in finding selective and sensitive probes as well as developing appropriate detection format based on sandwich and/or signal amplification assays.
This provides additional evidence that the limited signature overlap is most likely caused by small sample size difficulties.
The small knee joint size, difficulties with probe positioning, variation in the location of the needle tip and unanticipated animal limb movement during the injection are likely reasons why we were not able to visualise 25% of the injections.
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The article looks at how the evaluation team addressed various political, methodological, and theoretical challenges, including multiple stakeholders, small sample sizes, difficulty establishing well-defined "treatment" and "control" groups, and questionable instrumentation.
Although the Pacers' size presents difficulties for the Knicks — and perhaps contributed to Anthony's foul trouble in Game 1 — Woodson said he would stick with his small-ball lineup, with Anthony at power forward.
The conditions during early growth of individual organs are important determinants of final organ size, causing difficulties in incorporating effects of environmental stresses in such models.
Purchase of a large and expensive house becomes more distant vision for most people due to high initial cost, the size estimation difficulties, oversizing effects in higher mortgage and cost of maintenance.
The use of the old missile silo created a large set the budget would have prohibited building from scratch, but the small size created difficulties.
The MSM population is frequently referred to as "hidden" [ 9, 10] due to its unknown size and difficulties to reach.
Signatures that are derived from pooled datasets have been derived using more samples, thereby easing small sample size related difficulties.
Due to its enormous size and difficulties in obtaining a biochemically pure fraction, the molecular composition of the tight junction remains largely unknown.
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CEO of Professional Science Editing for Scientists @ prosciediting.com