More sizable sample based clinical investigations should be conducted before miR-155 can be applied as an auxiliary diagnostic biomarker.
This exploratory analysis did not indicate a sizable difference in clinical effectiveness between tocilizumab monotherapy and combination therapy.
In developed countries, approximately 4 per 100,000 persons per year develop bacterial meningitis, resulting in sizable outlays of monetary and clinical resources [32].
Previous studies have shown that AD-related thinning of particular cortical regions correlates with worse performance on cognitive testing in patients spanning a relatively broad spectrum of clinical impairment, including a sizable number of moderately demented patients (Lerch et al. 2005; Du et al. 2007).
Renal cell carcinoma is known for a sizable subset of tumors presenting at advanced clinical stage, further highlighting the importance and timeliness of this topic and its potential impact on adjuvant therapy.
Since ANA and related autoantibodies are generally considered useful biomarkers for AARD (which have low prevalences) and are included in the classification criteria for SLE [13], MCTD [14], SjS [15] and SSc [16], ANA testing on HEp-2 substrates outside a proper clinical framework may yield a sizable portion of ANA-positive individuals without consistent evidence of AARD.
Cost of chemotherapy-induced FN among NHL patients in European and Australian clinical practice is substantial; a sizable percentage is attributable to follow-on care and subsequent FN events.
We hypothesize based on our clinical experience that in a sizable minority of incident ESRD patients develop ESRD after suffering period of rapid loss of glomerular filtration rate (GFR) which may or may not fit the current definition of acute kidney injury (abrupt rise in serum creatinine of ≥0.3 mg/dl or ≥50% within 48 hours)[ 1].
It is quite obvious that ANA testing on HEp-2 cells outside a proper clinical specialist framework may yield a sizable portion of ANA-positive individuals without consistent evidence of AARD, purportedly leading to inappropriate referrals to tertiary care specialists, as well as anxiety in patients and physicians alike [3] and, perhaps, inappropriate and potentially toxic therapy [6].
Four previous studies reported that primary ICD implantation in routine clinical practice was associated with a sizable survival benefit comparable with those seen in major trials, 39 47 48 49 but only one 39 included the subset of elderly patients who underwent device implantation during an acute hospital admission.
