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Nevertheless, the lack of cooperativity for E2C-18 is due to compensating changes in enthalpy and entropy and is likely associated with sizable changes in the structure of the DNA that go beyond those expected for additive binding.
We observed sizable changes in the preference for helix azimuthal rotation when a key aromatic ring, the side chain of either residue 5 or residue 19, has been moved by 100° around the helix axis (Tables 3 and 4).
However, sizable changes in the average case severity (as measured by CMI) were observed only for hospital A which also happened to be the hospital with the lowest DRGs both just before and 2 years after the introduction of the policy.
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It is clear from these data that the hydraulic system designed based on the 10-year return period and 50-year return periods can have sizable change in the dimensions of the components.
As there is only marginal difference in rainfall amount between the 50- and 100-year return periods, the design based on either 50- or 100-year return period rainfall does not have sizable change in the dimension of the hydraulic components.
In conclusion, log transforming the environmental factors did not lead to sizable changes in interaction OR as compared to using the non-logged factors for our top findings.
The success of Mr. Colbert's program (its eight-week tryout was quickly extended to a year) came in a year of sizable changes in real broadcast news, most notably among the network evening newscasts.
Also, these peptides were chosen for detailed analyses because in their binding of the modified hASLLys3UUU, they exhibited sizable changes in fluorescence that could be accurately quantified.
The net-net is that this provision has been particularly challenging for startups, which often trigger this limiting condition, given they frequently operate in the red through growth stages and often see frequent, sizable changes in their ownership structure due to fundraising, public offerings and acquisitions.
These findings indicate that biochemical conversion to diabetes from pre-diabetes has limited significance for CVD complications of diabetes, although sizable changes in glycemia may have greater effects (20).
The figure shows only one example of a sizable change in strain rate in the E1 direction that was not associated with sub-Plinian eruptions or subsequent magma effusion.
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