Such high selection pressure may be capable of maintaining MHC polymorphism even in heavily bottlenecked populations; indeed an endangered canid, the island fox Urocyon littoralis is a rare example of such situation: variation at DRB locus is maintained despite depletion of neutral variation [ 64].
Second, there is a need to reach a certain degree of consensus regarding the conduct of ethical decision-making in end-of-life care taking into account of the tendency Japanese physicians' attitudes toward some different clinical situations; variations of specific treatments; withholding or withdrawal of treatment.
However, in other situations, variation in reported incidence over time may also be due to changing case reporting methods.
In such situations, variation in payoffs among individual players is again likely to affect the outcome and the probability of cooperation.
Complicating the real-world impact of very late stent thrombosis associated with DES is the widespread use of DES in off-label situations, variation and duration of antiplatelet therapy and inadequate follow-up periods in clinical trials to quantitate the risk of early stent thrombosis (≤30 days), late stent thrombosis (31 365 days) and very late stent thrombosis (>1 year).
Observation is an "as is" experiment or natural experiment where the researcher describes the "what is" situation and variations among variables that are manipulated by others or nature.
The second result from [12], inspired by Opial's paper [13], concerns the situation when variations of A k (1.6) need not be uniformly bounded and (1.1) and (1.4) reduce to homogeneous equations.
"This situation, with variations, is repeated unequally across the geography of the USA," it says.
This situation of variations in binding of transcription factors has been previously described in RA [ 11, 44].
The cumulative error introduced by these time, place and situation-dependent variations is referred to as batch effects.
