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Then protection of phenol with methoxymethyl chloride and subsequent hydrogenation of azide group by 10% Pd/C in situ protection with di-tert-butyl dicarbonate afforded 150.
Addition of DMF led to the in situ protection of the nucleobase with a formamidine group.
Selective hydrolysis of the thioacetate with hydroxylamine[ 11] and simultaneous in situ protection of the thiol with S- tert-butyl methanesulfonothioate gave S- tert-butyl disulfide 7.
The apparent pH must be kept around 4 to ensure a good in situ protection of ε-amino groups by protonation, which is essential for the chemoselectivity, whereas the hydrazide component remains nucleophilic because of its low p Ka (3.24 for acetylhydrazine).
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To compound matters further, the night shift and engineering chief squabbled over whether the reactor should be shut downFor several hours workers were in situ with minimal protection.
Even specific elements of CSR are conceived of differently, for example in China, the main understanding of sustainability is in terms of environmental protection (Situ et al. 2013, 2015).
Preparations that increase free radical scavengers in situ can offer protection from cellular damage and facilitate the process of tissue repair [ 40].
The design of in situ MMC for wear protection is discussed, which is based on the larger size of in situ TiC particles compared to conventional ones and on the cost reduction.
We report a robust in situ encapsulation method for protection of a variety of oil soluble solvents and reactive epoxy resins surrounded by a thin, polymeric, urea formaldehyde (UF) shell.
To study Mad expression in keratinocyte proliferation and differentiation, we have analysed Mad RNA expression in regenerating and hyperproliferative epidermal lesions and epidermal tumours of varying degrees of differentiation using the RNA in situ hybridisation and RNAase protection techniques.
While the relative merits of the two systems continue to be discussed [ 5], the validation of microarray results using independent mRNA quantitation techniques, including Northern blotting, ribonuclease protection, in situ hybridization, or quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) remains a critical element of any microarray experiment [ 6, 7].
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