Based upon the finding that MCOLN1 and AMPK genetically interact, we sought to identify possible sites of interaction (phosphorylation sites) in the TRPML1 protein.
In contrast, only a few interacting proteins/substrates have been observed for the other RBRs and the sites of interaction are not well defined.
Accumulating evidence attributes important biological roles to filamentation in stressful environments, including, but not limited to, sites of interaction between pathogenic bacteria and their hosts.
Furthermore, the molecular players should ideally be localized to sites of interaction between fine astrocytic processes and the axons of NPY interneurons using methods for high-resolution imaging.
Further, this system can be used to determine the stoichiometric composition of complexes and specific sites of interaction.
The modules define sites of interaction with the outer membrane transport genes, TonB, the immunity proteins, and the activity regions.
Crystallography has revealed that the ATP-binding site of CDK2 can accommodate a number of diverse molecular frameworks, exploiting various sites of interaction.
To address this issue, we synthesized a photo-crosslinking compstatin analog and used it to probe C3 for sites of interaction.
We compared the spatio-temporal distribution of mound and enclosure complexes in respect to sites of interaction between the two groups.
New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.
The principal sites of interaction in the endothelin ligand all lie on one face of a helix that has been implicated by structure-activity relationship studies as being essential for binding.
