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PML is the growth control protein that forms PML nuclear bodies, sites of control of cell proliferation, apoptosis and gene regulation [ 62, 63].
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To circumvent this issue, we avoided comparisons with standard neutral models and instead performed direct comparisons with approximately neutrally evolving sites, comprised of control promoter sites, synonymous sites, and internal intronic sites.
Although transcription is a major site of control, post-transcriptional mechanisms also play pivotal roles in regulating gene expression.
The second, Abi1-containing Wave 2 complex, has been directly linked to the effect of Rac1 on increased actin polymerization at the plasma membrane at the site of control of lamellipodia formation [32], [33].
On day 8 the wound site of control mice contained large amounts of collagen in the dermis (scar tissue) with few mononuclear cells and numerous distinct blood vessels (Fig. 2).
To determine if there were differences in lymphocyte infiltration into the transplant site of control or drug-treated animals, the numbers of CD4+ and CD8+ T cells within the hippocampus were estimated using unbiased stereology.
Another potential site of control is the cytochrome c oxidase (complex IV) reaction which is irreversible.
IDH3 activity regulates OGDH that is the primary site of control of the metabolic flux through the TCA cycle.
The enzyme carnitine palmitoyltransferase (CPT1) is located in the outer mitochondrial membrane and represents the main site of control for the entry of LCFA into the mitochondria [ 39].
In this section, the philosophical nature of women's bodies as a contested site of control and power, from which women's risk of HIV is elevated, is fleshed out.
The combination of these two methods allowed the authors to state that pyruvate extra- to intracellular transport was the primary site of control of the total HP lactate signal, though generalizing this conclusion to other situations should be done with circumspection.
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