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This area of CB1 expression might suggest the existence of a putative crosstalk between central and peripheral sites in the context of the roles of the cannabinoid system.
Emphasis is on the environmental microbes isolated from metal/radionuclide enriched sites in the context of nuclear waste disposal (Neu et al. 2010).
We attempted to confirm that OST1 phosphorylates the predicted sites in the context of the entire ABF3 protein.
Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were randomly inserted into the genome by transfection.
Further studies are required to determine if the binding site specificity we observed is an intrinsic property of HLH-1 or reflects additional constraints, including required cooperativity with other factors or the limited accessibility to potential binding sites in the context of general or tissue-specific chromatin organization.
In order to address the potential functional role of the three intragenic AP-1 binding sites in the context of the whole 5103 fragment, we inserted this 264-bp fragment into the pTK reporter construct immediately upstream of the TK-luciferase transcriptional unit in the sense or antisense orientation, thereby generating the pTK-5103s-wt pTK-5103s-wt pTK-5103s-wtspectively.
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Mutation of this site in the context of 1.1 kb of the Icam-1 promoter significantly abrogated transcriptional induction by phorbol ester and anti-mu stimulation in primary B cells.
The results show that exposing FMDV-VP1 major neutralizing antigenic site in the context of N-terminal sequences of the VSV G protein can overcome the immunological limitations of FMDV-VP1 peptides as effective protein and DNA vaccines for cattle.
We examined whether DAZL's effect is specific to the miR-430 target site in the context of tdrd7 3'UTR.
We analyzed the position of the hippuristanol binding site in the context of a model based on the domain orientation of eIF4AIII in the exon junction complex (EJC) (PDB code 2HYI) [23], [23] (Fig. 1D).
To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12.
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