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Ethnic sensitivities on mutation sites, frequencies, and clinical implications remain unclear.
In addition, simulation of intron insertion into protosplice sites with the observed protosplice sites frequencies and intron densities showed that parallel gain could account for only 5-105-10%shared intron positions in distantly related species.
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Among the 22 study sites, frequency of ALI development varied from less than 1 % to more than 12%% after adjustment for APACHE II.
Of these SNPs, c. 44.0% (930) were common sites (frequency ≥ 0.05) (Supplementary Table S4).
High frequency interactions (10 interaction sites, frequency 0.1 s-1) make the state switching more rapid and induce a more stable chromatin composition.
Previous algorithms have used transcription factor binding site frequencies [17], the size and location of CpG islands [18], and the physical properties of the DNA.
As an additional control, we used intergenic regions from human and fruit fly (see Methods) and measured the RP-site frequencies in those regions.
The same approach was used for Rap1 binding-site frequencies.
YZ calculated intron splice site frequencies and homology among human, mouse, and rat orthologs.
Initial population frequencies of both BOXA and BOXC were obtained by determining the equilibrium binding site frequencies prior to the introduction of mutant SPC into the population.
Better models to calculate restriction RS probabilities across taxonomic groups are needed to improve the accuracy of predictions of cleavage site frequencies in species without sequenced genomes.
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