Fig. 1 Active site composition of subfamilies of mononuclear Mo/W enzymes.
Using this approach, the site composition of five defined sites with increasing size up to 8 nm was obtained.
The pharmacophore feature arrangement was found to be in good agreement with the binding site composition of the receptor model, but the excluded volumes did not fully reflect the shape of the agonist binding pocket.
The amino acid replacements in SP1 occurred independently at the same position along the bird and eutherian mammal lineages, driving convergent modification of the zf2 structure as well as the binding site composition of its target genes.
To estimate the functional impact of alternative splicing, we predicted changes in domain, motif, and miRNA binding site composition of protein sequences for alternatively regulated exons in stage 1-, 4-, and 4+ tumors [ 17].
This corresponds to the null hypothesis that the two sequences independently mirror some aspects of the binding site composition of training CRMs, and thus provides a strong baseline to contrast with the homology model where they share sites for the same motifs.
The CART method has already been used to classify acetylated or methylated promoters based on the binding site composition of a set of differentially expressed genes [ 35] or to identify relationships between gene expression levels and regulatory motifs in microarray experiments [ 36].
Three histidines and one aspartate are conserved in CREST proteins, reminiscent of the active site composition of several well-studied metal-dependent hydrolases such as thermolysin [ 63], bovine carboxypeptidase A [ 64], D-Ala-D-Ala carboxypeptidase [ 65] and the intramembrane S2P-like proteases [ 66].
First, we reviewed transit vaccinations to estimate the proportion of total vaccinations achieved at transit sites and to examine the association between polio vaccine delivery and various factors (e.g., type of transit site, community composition of teams).
The A-site elemental composition of the resultant particles was correspond linearly to the molar ratio of the Ca2+ and Ba2+ in molten salt.
