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Importantly, in cBAF-perturbed cancers, ncBAF complexes maintain gene expression at retained CTCF-promoter sites and function in a manner distinct from fusion oncoprotein-bound complexes.
Homeostatic chemokines are primarily expressed at lymphocyte-homing sites and function to maintain homeostasis and regulate homing and lymphocyte maturation.
However, seventeen of the 44 contain only SPI-1 binding sites and function in defense response, the pentose phosphate shunt, inositol phosphate signaling, and S100A signaling.
In the context of nuclear structure, a significant portion of LINEs seem to be ORC-binding sites and function as MARs.
However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood.
In addition to the VvSUC and VvHT, it would be interesting to see the expression sites and function of VvSWEET (Vv14G09070) for long distance sugar transport during flower and/or berry development in V. vinifera.
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Table 1 O-GlcNAcylation sites and functions of histone tails.
As a project manager, my role as a team member of projects that affect multiple sites and functions of my company's Operations division affords me the opportunity to work on initiatives that are critical to our bottom line.
As a cellular response to DSBs, p53 binding protein (53BP1) is recruited to damage sites and functions as a promotor of DNA repair processes.
This Bem3-containing compartment was present during extended periods of apical growth, required actin tracks for trafficking to polarized sites and functioned as a recycling station that was positioned at the junction of endocytic and secretory pathways.
Bzz1, acting at the invagination base, stabilizes endocytic sites and functions with Rvs161/167, localized along the tubule, to achieve proper endocytic membrane geometry necessary for efficient scission (Kishimoto et al., 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com