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The structure reveals an extended RNA path to Rrp6 that penetrates into the non-catalytic core; contacts between the non-catalytic core and Rrp44, which inhibit exoribonuclease activity; and features of the Rrp44 exoribonuclease site that support its ability to degrade 3′ phosphate RNA substrates.
They also carry out some mutations around the active site that support nucleotide-mediated catalysis, although this point in not rigorously proven because the data are negative (i.e., mutations do not affect catalysis substantially).
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The videos are created on the Adventr site but can then be posted to Facebook, Twitter, and on any site that supports the VPAID format.
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