Sentence examples for site specific introduction from inspiring English sources
The site specificity of the radiolabeling is achieved only by site specific introduction of an aryl iodide into the biomolecule by either chemical methods or genetic modification.
Methods for the site specific introduction of reactive thiols and other unique reactive functional groups must be utilized to develop novel, active, biological radiotracers.
The site-specific introduction of non-canonical amino acids into polypeptides through genetic code reprogramming has become a powerful tool for biochemical studies and bioorganic synthesis.
Furthermore, reaction with an aldehyde-containing reagent termed GS-Al results in site-specific introduction of an orthogonal handle for subsequent conjugation with aldehyde-reactive probes.
Given the possibilities in protein engineering, it is not surprising that an enormous amount of effort has gone into the development of approaches for the site-specific introduction of unnatural amino acids into proteins.
Recently the site-specific introduction of chemical linkers has been reported through unnatural amino acid insertion.
Site-specific introduction of probes into target proteins is a topic of intense interest for studying structure activity relationships.
36 Thus, the aldehyde tag serves as a means for site-specific introduction of azides or cyclooctynes onto recombinant proteins through small-molecule linkers.
27– 31 However, harnessing these qualities for heterobifunctional protein conjugate synthesis first requires a practical route for the site-specific introduction of the necessary reactive partners.
The site-specific introduction of a C label at the γ carbon, and a N label at N-dG enables the equilibrium chemistry of γ-OH-PdG adduct 2 to be monitored, in situ.
Importantly, site-specific introduction of constitutive 14-3-3 14-3-3 14-3-3 into Gabindingersitesrefractory to receptor actintoion, demonstratinGab2at site-selective binding of 14-3-3 prenders it sufficient to terefractoryb2 signalling.
