Sentence examples for site shape from inspiring English sources

Different clustering algorithms were then used to extract the present information on binding site shape differences.

In order to close this gap in ligand design a new method for binding site shape clustering was developed based on the test case PTP1B/TC-PTP.

When mutations cause a high population of ON or OFF states, or lead to an irreversible change in active site shape and dynamics, the allosteric diseases occur [13].

We developed a mammalian model considerably closer to human aromatase in order to study the active site shape with new potent aromatase non-steroidal inhibitors.

The binding site shape information derived from the grids was translated into a matrix containing binary data for presence or absence of each point inside the binding site of the corresponding frame.

Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Cα RMSD <1 Å, >85% side chain identity, and ≥80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry.

Since the site shapes the pictures, is it not, indeed, their co-author?

In the end, she said, the specialized approach she developed through the Web site shaped the future of the brokerage itself.

Here, 12 full-size authentic wooden Russian houses, their balconies bursting with scarlet flowers, stand among overgrown orchards on a site shaped by Lenne like a Roman hippodrome, with a diagonal St. Andrew's cross of roads through its heart.

Damage areas, damage site shapes and crater depths were measured at every certain fatigue cycles.

This way, binding site shapes with high probability in PTP1B, but low probability in TC-PTP can be discovered and the evidence can be used to select favourable shapes and interaction points for selective PTP1B inhibitors.