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Figure 1: A toy HMM for 5′ splice site recognition.
Specifically, the structural details of splice site recognition and the architecture of the spliceosome active site are poorly understood.
Based on these results, we present a simple model for the mechanism of microRNA target site recognition.
Sok, D. et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.
Chevalier, B., Turmel, M., Lemieux, C., Monnat, R. J. Jr. & Stoddard, B. L. Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI.
Prieto, J. et al. The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage.
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As a simple example, imagine the following caricature of a 5′ splice-site recognition problem.
Baskaran, S., Ragusa, M., Boura, E. and Hurley, J. H. Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy.
Example 2. One more example case will be considered, that is involving acceptor splice-site recognition.
Similarly, PUF60 may be required in addition to U2AF65 and U2AF35 to facilitate splice-site recognition.
We now provide direct evidence that PUF60 is a splicing factor involved in 3' splice-site recognition.
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