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These bioresponsive nanosystems present several unique features such as no need of an external device, precision control over site of response (from tumor tissue down to cellular organelle level) following accumulation in the tumor via either passive or active targeting, and spontaneous activation in the tumor site or inside the tumor cells.
It is noteworthy that these models all include some action at the plasma membrane, which is also the suggested site of response to cold stress.
aFrom left to right are fields for responder or site of response, site address, date of pick-up, date of intake, bag contents, location of testing, comments, priority, swab taken (yes, no), and patient (if clinical sample).
When stratified according to site of response, 11 (31%) patients had a partial response at sites of extraovarian metastases and only five (14%) had a partial response in the ovaries.
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Sites of response were similar in both groups.
The sites of response were lung and lymph nodes for both patients.
Sites of response included soft tissue/nodal (three patients) and lung (one patient).
A whole promoter method focused on key single CpG site predictors of response to therapy might have an advantage over semi-quantitative approaches focused on a single region.
Second, placing the occlusion cuff above the site of hyperaemic response measurement might evoke a dilatory response that is related in part to ischaemia and, therefore, is not entirely mediated by NO.
For example, activated ERK1/2 could phosphorylate the Ser133 site of cAMP response element-binding protein (CREB), thus leading to the activation of CREB and the transcription of cAMP response element (CRE -related genes, finally induCRE -relatedmation of LTP [ 27].
The site of toxic response can be local (at the site of first contact or portal of entry of the chemical) or systemic (produced in a tissue other than at the point of contact or portal of entry).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com