Sentence examples for site of function from inspiring English sources

However, since the site of membrane insertion (or removal) is often distant from the site of function, the lateral mobility of single receptor molecules must be taken into account to understand how their synaptic aggregation and function are regulated.

Since cystatin C is a secreted protein, its major site of function is in the extracellular compartment [ 7, 8].

Once targeted to its site of function, PIPKIγ_i2 then generates PtdIns(4,5) P2, which regulates the activities of proteins in the vicinity.

Therefore, CBs are currently thought to provide a location where various components and sub-complexes can be assembled before they are released to the site of function (Shaw and Brown 2004).

Since their discovery, however, ESCRTs have been recognized as playing important roles at the plasma membrane, which appears to be the original site of function for the ESCRT machinery.

Once exposed to the ER lumen, polypeptides are folded, assembled and may undergo post-translational modification, such as N-linked glycosylation, prior to being transported to their site of function.

Proteins that reside in endomembrane organelles, or that are secreted from the cell, reach their sites of function by transport of the endomembrane system [ 67].

The ER functions to both co- and post-translationally modify newly synthesized proteins and lipids and sort them for housekeeping within the ER and for transport to their sites of function away from the ER.

The ER functions to both co- and post-translationally modify newly synthesized proteins and lipids and sort them for housekeeping within the ER and for transport to their sites of function away from the ER (Palade 1975).

The human ileal epithelial layer consists of multiple cell types (goblet, enteroendocrine, Paneth, absorptive enterocytes) that simultaneously differentiate from stem cell progenitors as they migrate toward their sites of function along the villus-crypt axis.

The first retrograde Golgi-to-ER pathway described was the KDEL-receptor mediated transport of luminal ER proteins (Lewis and Pelham 1990; Munro and Pelham 1987; Semenza et al. 1990), which following the export out of the ER together with the flow of multiple other proteins destined for transport to other destinations have to be retrieved to their sites of functions in the ER.