The presence of prolactin receptor in both benign and malignant male breast tissue varies according to the site of expression; benign lesions only express the receptors on the luminal surface of epithelial cells, while malignant lesions show cytoplasmic expression [ 54- 56].
The site of expression was localized: TLR2 was strongly expressed in mucosal epithelial cells and weakly expressed in mucosal infiltrating lymphocytes.
We further identify and discuss co-expressed genes regulated after diapause in light of the underlying site of expression, functions, maternal contribution and evolutionary conservation characteristic of these groups.
For the expression study of hepcidin, the liver tissue was chosen, as it is the main site of expression of hepcidin (Krause et al. 2000).
In summary, a second form of CYP3A with steroid hydroxylase activity, CYP3A45, has been cloned from rainbow trout and the major site of expression was in the intestinal tissues.
Furthermore, our study confirms the role of fish skin as an important extra-hepatic site of expression of complement molecules as well as an active regulator of complement expression.
Using immunohistochemistry and confocal laser microscopy, we localised the site of expression of the translated PTGER4 transgene to the plasma membrane compartment (Figure 2B).
In our study, we only examined the mice for overt thymic lymphomas as this was the site of expression of Casp9DN.
One can take advantage of sample structural diversity to identify the site of expression of a gene, through selection of subgroups of samples with different compositions.
Another preferential site of expression was the developing CNS: 3/5 mouse lines showed transient fiZ expression in the spinal cord and hindbrain at E11.5 to E12.5 (fig. 4C D).
It can be seen that functional redundancy with respect to the site of expression was evident for all regulatory elements, a notion concordant with findings in other genes [53].
