The first FDA-approved PEGylated proteins, Adagen® and Oncaspar®, were heterogeneous multi-PEG mixtures that differed in the number of attached chains and the site of attachment [ 36].
For example, flying birds have a keel a ridge on the sternum, or breastbone, which is a main site of attachment for flight muscles.
"It only works at the site of attachment with the Sertoli cells so they don't affect the hormones of the male.
The arrangement of placentae (placentation) in the compound ovary of angiosperms is characterized by the presence or absence of a central column in the ovary and by the site of attachment (Figure 14).
This allows for the construction of a well-defined, oligosubstituted enzyme ligand conjugate for which the site of attachment of the ligand on the enzyme is known precisely.
This avoids the problems associated with covalent attachment of the ligand to the enzyme, such as multiple substitution of the ligand and variability of the site of attachment.
From the correlations between the glucose H-2´´ protons and the acetyl C = O carbon atoms in the HMBC spectra, we deduced that the site of attachment was the C-2´´ hydroxyl group.
A fracture was defined as a disruption of at least one of the cortices of the wrist or an osseous avulsion at the site of attachment of a ligament or tendon.
We established the site of attachment of the glucose moiety to the flavonoid as being the C-3 position, due to the correlation found between proton H-1´´ and C-3 in the HMBC spectra.
It is a rare entity and must be differentiated from various other entities like chondrocalcinosis, avulsion at the site of attachment of posterior cruciate ligament or the posterior horn of the meniscus, and avulsions of the semimembranosus tendon, as well as from a loose body, as it requires different management.
The Pup site of attachment was identified for 55 proteins, including the previously characterized FabD (Tables 1, S2) [9].
