This article discusses the polymer structural features that enable effective intracellular delivery of DNA and RNA, including protection of nucleic acid cargo, cellular uptake, endosomal escape, vector unpacking, and delivery to the intracellular site of activity.
Proteins like Duf and SNS localise to this focus suggesting that this might be their site of activity during fusion [21].
Native polypeptides released from the Calnexin chaperone system are de-glucosylated by the α-glucosidase II, exit the ER and are transported at their intra- or extracellular site of activity.
The exact site of activity of LKR/SDH is considered to be the mitochondria [ 11], but evidence is not clear.
The carboxy termini of proteins are a frequent site of activity for a variety of biologically important functions, ranging from post-translational modification to protein targeting.
One of the most direct avenues for acquired resistance is the up-regulation and engagement of efflux pumps to effectively remove the drug from its site of activity.
Besides, the major site of activity of p300 is in the nucleus where it regulates critically important processes like transcription and DNA repair [ 26- 28].
These chaperones function by binding to the enzyme and stabilizing its fold, allowing it to reach its site of activity, i.e. the lysosome.
The kidney is the second site of activity where 1α-hydroxylase (cytochrome P450 27B1) converts 25(OH D to 1,25-dihydroxyvitamin D2 or D3 (calcitriol) (1, 2).
If genes could be categorised in this way, we endeavoured to place them on a simplified Kyoto Encyclopedia of Genes and Genomes (KEGG) apoptosis pathway to give an indication of their likely site of activity within the apoptotic pathway.
