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It is also suggests that cerebellum may be a site of action of CGRP receptor antagonists.
This points toward a central site of action for the migraine-promoting role of CGRP.
Thus, indomethacin-resistant HC mean a headache that lacks this indomethacin specific site of action.
A potential answer would be a site of action outside the blood-brain barrier.
All these findings taken into account suggest a peripheral vascular site of action of the mAbs.
Moreover, intracellular delivery of Dtx NPs allows a drug accumulation near the site of action [23].
The preparation allows evaluating the trigeminal brainstem as a pharmacological site of action.
More details about these tests are found in the site of Action (Portal Action 2015).
The second question is related to the site of action of CGRP.
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Furthermore MR-angiography is useful in determining the vascular site-of-action of vasoactive substances.
These studies show that phMRI can be a powerful tool in understanding mechanisms and site-of-action of pharmacological compounds.
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