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The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or near the injection site are explained in the Preamble section.
Only hemizygous BBL-2 animals were examined because the insertion is homozygous lethal (genotyping was performed following identification of the transgene insertion site; Methods).
Further details regarding the study site, methods used for data collection and previous research on this population can be found in Clutton-Brock and Pemberton [21].
Following the success of the array at the Wave Hub site, methods of deployment were further developed to characterise the seabed in stronger tidal stream conditions, east of Guernsey (Channel Islands) between the islands of Herm and Sark.
We thus further extended PIPES to incorporate phastCons scores [ 35] for each site (Methods).
The site methods described in this paper may be used to predict functionally important residues in gene family members.
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The numbers of squares selected by complementarity-based algorithms were similar to those by the hotspots and irreplaceable site method.
GCF characteristics (Table 4): time, room temperature and humidity during GCF collection, site, method of collection of GCF, storage and handling characteristics, and technique of mediator analysis. .
ETA had significantly higher (7x) sensitivity than ProFunc's Enzyme Active Site method, which relies on known catalytic sites.
Several methods were developed to test for positive selection that acts on given branches (branch method), on a subset of sites (site method), or at individual sites along specific branches (branch-site method) [ 66- 68].
Precore A1896 mutant was detected by amplification-created restriction site method, as described before (Chu et al, 1996).
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