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It is a primary site for recognition and binding of various pathogens and thus a promising therapeutic target for inhibition of pathogen entry and subsequent prevention of immune defense cell infection.
In this study, we identified that a similar FQ motif within Fbxl7 is the major docking site for recognition by Fbxl18.
While the N-terminal arch, besides mediating the interaction with FG-repeats of nucleoporins, forms the RanGTP binding site, the C-terminal arch is the major contact site for recognition of cargo.
This data supports AVR-Pik as a key site for recognition specificity, and that following introduction of Pikp into cultivated rice, M. oryzae evolved to evade recognition by mutating this residue.
It is only after translocation of the IRES by eEF2 that PKI can move into the P site, thus bringing the first codon of the mRNA into the A site for recognition of a cognate tRNA brought as a ternary complex by eEF1A and GTP.
Because the EF and CD loop structures are exposed on the viral surface of cardioviruses and thus constitute an important site for recognition by neutralizing antibodies (15 ), Can112051-06 and the original SAF-V might represent different serotypes, although further serologic studies are needed to confirm this hypothesis.
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A benzthiazole-based multifunctional chemosensor was designed with siderophores like binding sites for recognition of Fe3+ and both hydrogen bond donor and acceptor binding sites for oxyanion HSO4−.
Thus KAP-βs likely possess multiple binding sites for recognition and transport of the wide range of cargo.
GSTs have two active sites per dimer, with each active site separated into two distinct functional regions: a hydrophilic "G-site" for recognition of GSH, and an adjacent "H-site" for binding hydrophobic electrophiles.
These proteins act by selecting splice sites for recognition by the spliceosome through binding to intronic or exonic splice enhancer and silencer elements and promoting or destabilizing protein interactions with spliceosome components.
By substituting an HIV protease site for the recognition site of the IgAse, we also obtained a substrate for the quantitative and sensitive detection of HIV-1 endoprotease.
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