The total angle-weighted relative opportunity for movement (to one of the S sites) due to directed migration is thus AS/(AS+1) where A is the average of the cos over these sites.
The total angle-weighted relative opportunity for movement (to one of the S sites) due to directed migration is thus AS/(AS+1) (we correct a misprint) where A is the average of the cos over these sites.
One important aspect of monocyte function is chemotaxis, i.e. directed migration to sites of inflammation, neoangiogenesis or collateral growth, i.e. arteriogenesis.
Additional granulocytes are attracted and directed to the sites of infection in a process called directed migration, or chemotaxis.
In a number of cancer types, binding of its cognate ligand CXCL12 [10] was reported to mediate directed migration of cancer cells to sites of metastasis [9], [11].
However, recently a clinical study has hinted that the wound environment triggers directed migration of melanocytes to the wound site (Sugata et al., 2008).
Chemokine receptors are critical to the innate immune response since their activation results in the directed migration of inflammatory cells to the site of infection (Murdoch and Finn, 2000).
In breast cancer, it has been found that secondary site tumor colonization during cancer metastasis is not random, but rather there is directed migration of CXCR4-expressing cancer cells towards the SDF-1 ligand at common secondary sites such as lungs and bone marrow [43].
This novel function of CD152 could explain the retention and directed migration of effector cells to secondary lymphoid organs and sites of antigenic-challenge and might be important for T cell homeostasis as well as Th1-dominated diseases.
Chemokines are known to induce the directed migration of bone marrow CD34− mesenchymal stem cells (MSCs).
In addition, directed migration was further enhanced by increasing the RGDS gradient's slope.
