Sentence examples for site conserved from inspiring English sources

Not only is the area immediately surrounding the UDP-GlcNAc-binding site conserved, but also a path of high sequence conservation is observed from the active site groove, where the O-GlcNAc acceptor peptides are expected to bind, all the way into the TPR repeats, which have been shown to be important for substrate specificity (Lubas and Hanover, 2000; Iyer and Hart, 2003).

Moreover, for additional analyses, the lists of 'highly conserved targets' were defined as mRNAs with a specific binding site conserved both in mammals (humans, mice, rats, dogs) and in chickens.

And the common active site conserved amino acid pattern SXnYXXXK was emerged at the mid-chain pattern 142 159, as well as the NNAG (89 92) sequence which has a function in stabilizing β-strands of classical SDR (Persson et al. 2003; Filling et al. 2002).

Examination of the mouse proximal NTCP promoter region identified a consensus DBP binding site conserved in several mammalian species (Figure 7A).

Finally, a two nucleotides mutation of an EGR-1 site, conserved in all species including human and zebrafish and located at a short distance from the TSS, destroyed the promoter activity of the −5.0 Kb promoter.

The data obtained reveal some similarities with the human promoter and identify an EGR-1 binding site, conserved also in man and mouse, which is essential for prep1.1 transient expression in zebrafish embryos.

Only conserved binding sites (conserved in mouse, human, rat and dog) were considered.

Upperlined sequences represent putative ATP and NAD(P H-binding sites, conserved Glu-5-kinase and GSA-DH domains, and leucine (Leu)-rich regions.

The encoded proteins included amino acid sequence motifs of serine proteinase active sites, conserved cysteine residues, and both zymogen activation and signal peptides.

This weighting scheme assigns a higher weight to motif sites conserved in distant orthologs in their contribution to the motif WM than to sites conserved in close orthologs.

Using bioinformatics programs (see Materials and Methods), we identified several putative binding sites conserved between species.